A field experiment was conducted during the early summer season at Tamil Nadu Agricultural University, Coimbatore, to evaluate the System of Crop Intensification (SCI) practices in sesame. The experiment was laid out in Randomized Complete Block Design, comprised of ten treatments and replicated thrice. The results revealed that closer square planting of sesame at 30 × 30 cm with TIBA application @ 50 ppm at 30 DAS and hand weeding at 35 DAS (T2) showed its superiority in recording the higher plant height, number of branches m-2, LAI and drymatter production, number of capsules m-2, seeds capsules-1, test weight and in producing greater seed yield, stalk yield, harvest index and economic profit than the control and any other treatments tested in the study.